ISSN 2149-2263 | E-ISSN 2149-2271
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Volume : 25 Issue : 1 Year : 2021
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How did the updated hemodynamic definitions affect the frequency of pulmonary hypertension in patients with systemic sclerosis? [Anatol J Cardiol]
Anatol J Cardiol. 2021; 25(1): 30-35 | DOI: 10.14744/AnatolJCardiol.2020.46625

How did the updated hemodynamic definitions affect the frequency of pulmonary hypertension in patients with systemic sclerosis?

Alper Sarı1, Yusuf Ziya Şener2, Berkan Armağan1, Levent Kılıç1, Ergün Barış Kaya2, Vedat Hekimsoy1, Ömer Karadağ1, Şule Apras Bilgen1, Sedat Kiraz1, Ihsan Ertenli2, Lale Tokgozoğlu1, Ali Akdoğan2
1Department of Rheumatology, Faculty of Medicine, Hacettepe University; Ankara-Turkey
2Department of Cardiology, Faculty of Medicine, Hacettepe University; Ankara-Turkey

Objective: Pulmonary hypertension (PH) is a one of the major causes of death in patients with systemic sclerosis (SSc). In this study, we investigated the impact of updated hemodynamic definition proposed by the 6th PH World Symposium (6th WSPH) on the frequency of PH and its subtypes in patients with SSc.
Methods: Patients with SSc admitted between 2015 and 2019 and who underwent right heart catheterization (RHC) were included. The frequency of PH and its subgroups based on the hemodynamic definitions of both 2015 European Society of Cardiology/European respiratory Society (ESC/ERS) PH guidelines and 6th WSPH was compared.
Results: Of the 65 patients with SSc, 23 (35.4%) had normal mean pulmonary arterial pressure (mPAP), 20 (30.8%) had mildly elevated mPAP (21–24 mm Hg), and 22 (33.8%) had PH [pulmonary arterial hypertension (PAH) (n=16, 24.6%), group 2 PH (n=5, 7.7%), group 3 PH (n=1, 1.5%)] according to the 2015 ESC/ERS PH definition. Based on the updated criteria, 7 (10.8% of total cohort) additional patients were reclassified as having PH [PAH (n=3), group 2 PH (n=3), group 3 PH (n=1)].
Conclusion: The impact of the updated definition on the frequency of PH and PAH in our cohort was greater than previously reported, which may be caused by the difference in screening strategies for PAH.

Keywords: systemic sclerosis, pulmonary hypertension, updated definition

Alper Sarı, Yusuf Ziya Şener, Berkan Armağan, Levent Kılıç, Ergün Barış Kaya, Vedat Hekimsoy, Ömer Karadağ, Şule Apras Bilgen, Sedat Kiraz, Ihsan Ertenli, Lale Tokgozoğlu, Ali Akdoğan. How did the updated hemodynamic definitions affect the frequency of pulmonary hypertension in patients with systemic sclerosis?. Anatol J Cardiol. 2021; 25(1): 30-35

Corresponding Author: Alper Sarı, Türkiye