ISSN 2149-2263 | E-ISSN 2149-2271
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Volume : 25 Issue : 9 Year : 2021
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Thrombosis, an important piece in the COVID-19 puzzle: From pathophysiology to therapy [Anatol J Cardiol]
Anatol J Cardiol. 2021; 25(9): 601-608 | DOI: 10.5152/AnatolJCardiol.2021.475

Thrombosis, an important piece in the COVID-19 puzzle: From pathophysiology to therapy

Elena Bobescu1, Luigi Geo Marceanu2, Alexandru Covaciu1, Larisa Alexandra Vladau1
1Department of Medical and Surgical Specialties, Faculty of Medicine, Transilvania University of Brasov; Brasov- Romania;Department of Cardiology, Clinical County Emergency Hospital Brasov; Brasov-Romania
2Department of Medical and Surgical Specialties, Faculty of Medicine, Transilvania University of Brasov; Brasov- Romania

A lot of data about coronavirus disease 2019 (COVID-19) have been already published; however, these still form only a part of the pandemic puzzle. Once we have all the pieces of the puzzle, we will be able to successfully treat this disease with its multiple challenges. COVID-19 has a high thrombogenic potential. In this study, we aimed to review published data about COVID-19 associated thrombosis from pathophysiology to treatment and the role in patient evolution. We searched for articles and studies published online through MEDLINE/PubMed database, Google Scholar, ScienceDirect, Wiley Online Library, and Nature Public Health Emergency Collection. We found numerous articles regarding COVID-19 infection but selected only those focused on thrombosis. D-dimers have a predictive value in identifying thrombosis and a high level correlates with the severity of the infection and death. Most patients who were on chronic anticoagulant therapy before contracting the virus had a better prognosis. Heparin has other favorable effects such as a direct antiviral and anti-inflammatory effect in addition to its anticoagulant effect. COVID-19 infections are frequently complicated by thrombotic pathology. High plasma level of D-dimers is a predictive factor for severe prognosis, and the recommended anticoagulant, associated with low mortality, is heparin followed by a direct oral anticoagulant. Randomized studies in large groups of patients and therapeutic guidelines are still needed on this subject.

Keywords: coronavirus disease 2019, thrombosis, anticoagulant agents, telemedicine

Elena Bobescu, Luigi Geo Marceanu, Alexandru Covaciu, Larisa Alexandra Vladau. Thrombosis, an important piece in the COVID-19 puzzle: From pathophysiology to therapy. Anatol J Cardiol. 2021; 25(9): 601-608

Corresponding Author: Elena Bobescu, Romania