ISSN 2149-2263 | E-ISSN 2149-2271
The effect of paclitaxel-eluting stents on restenosis [Anatol J Cardiol]
Anatol J Cardiol. 2006; 6(1): 18-23

The effect of paclitaxel-eluting stents on restenosis

Hürkan Kurşaklıoğlu1, Cem Köz2, Atila İyisoy1, Tayfun İde4, Vedat Yıldırım5, Hasan Fehmi Töre6, Ersoy Işık7, Ertan Demirtaş8
1Department of Cardiology, School of Medicine, Gülhane Military Medical Academy, Ankara, Turkey
2Department of Cardiology, Faculty of Medicine, Gülhane Medical Academy, Ankara, Turkey
3Department of Cardiology, School of Medicine, Gülhane Military Medical Academy, Ankara, Turkey
4Gülhane Askeri Tıp Akademisi Hayvan Araştırma Anabilim Dalı, Ankara, Türkiye
5Gülhane Askeri Tıp Akademisi Anestezi ve Reanimasyon Anabilim Dalı, Ankara, Türkiye
6Gülhane Askeri Tıp Akademisi Kardiyoloji Anabilim Dalı, Ankara, Türkiye
7Department of Cardiology School of Medicine, Gülhane Military Medical Academy, Etlik, Ankara
8Department of Cardiology, Yeditepe University Hospital, Kozyatağı İstanbul,Turkey

Objective: In our study we aimed to investigate the effects of paclitaxel-eluting stent on restenosis. Methods: Sixteen porcine were randomly assigned to two groups (n=8 per group): control group animals received conventional stent imp- lantation and study group animals -paclitaxel-eluting stent implantation. Both groups were treated with 300 mg acetylsalicylic acid and 75 mg clopidogrel daily. The degree of neointimal proliferation and effect of drug-eluting stent on restenosis were evaluated 6 weeks af- ter by angiography and intravascular ultrasound (IVUS). Results: Angiographic in-stent restenosis was lower in paclitaxel-eluting stent group (12.50 ± 7.07% versus 41.25 ± 28.50%, p=0.001). The IVUS data demonstrated that paclitaxel group animals had larger minimal lumen area (8.76 ± 1.09 mm2 versus 6.23 ± 3.10 mm2, p=0.028), smaller mean neointimal proliferation area (1.03 ± 0.75 mm2 versus 3.55 ± 2.86 mm2, p=0.01) and mean percent stenosis (10.71 ± 8.10% ver- sus 36.85 ± 30.93%, p=0.01). Conclusion: This study suggests that drug-eluting stents may also have a preventive effect for the in-stent restenosis.

Keywords: Paclitaxel, porcine model, restenosis, stent, intravascular ultrasound

Hürkan Kurşaklıoğlu, Cem Köz, Atila İyisoy, Tayfun İde, Vedat Yıldırım, Hasan Fehmi Töre, Ersoy Işık, Ertan Demirtaş. The effect of paclitaxel-eluting stents on restenosis. Anatol J Cardiol. 2006; 6(1): 18-23
Manuscript Language: English

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