Objective: Surgery is considered as a relative contraindication in sarcoma tumor. Due to the special of heart, whether surgery is an optimally chooses in primary cardiac sarcoma (PCS) is unknown. This study aimed to evaluate the 1-year survival of surgery for PCS.
Methods: PCS patients from the Surveillance, Epidemiology, and End Results Database (SEER) between 1975 and 2015 were recruited. The endpoint was defined as 1-year all-causes mortality(ACM) and 1-year cancer-specific mortality(CSM).
Results: The study population consisted of 335 patients diagnosed with PCS. The 1-year ACM & CSM were 49.0% and 42.1% respectively. The Kaplan-Meier curves revealed that decreased 1-year ACM & CSM were significantly associated with treatment of surgery. Multivariate COX regression analysis, surgery and chemotherapy showed significant decreased rate of 1-year ACM & CSM. The adjust HR of surgery were significant in the year of diagnosis(>=2000), age(<50), SEER stage (localized), and chemotherapy (No) (all p <0.05), and insignificantly in year of diagnosis(<2000), age(>=50), SEER stage (distance, regional, and unstage/unknown) and chemotherapy(Yes) (all p >0.05). None interactive effects between variables and surgery were detected (all p for interaction >0.05).
Conclusion: Surgery should be highly recommended in patients with primary cardiac sarcoma to improve 1-year survival rate, especially in younger, localized of SEER stage, and non-chemotherapy management.
KEY WORDS: primary cardiac sarcoma; surgery; subgroup analysis