ISSN 2149-2263 | E-ISSN 2149-2271
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Histopathological Changes in the Myocardium Caused by Energy Drinks and Alcohol in the Mid-term and Their Effects on Skeletal Muscle Following Ischemia-reperfusion in a Rat Model [Anatol J Cardiol]
Anatol J Cardiol. 2023; 27(1): 12-18 | DOI: 10.14744/AnatolJCardiol.2022.2003

Histopathological Changes in the Myocardium Caused by Energy Drinks and Alcohol in the Mid-term and Their Effects on Skeletal Muscle Following Ischemia-reperfusion in a Rat Model

Aylin Demirel1, Serdar Başgöze1, Kübra Çakıllı2, Ünal Aydın1, Gözde Erkanlı Şentürk2, Vesile Örnek Diker3, Mehmet Ertürk4
1Department of Cardiovascular Surgery, University of Health Sciences, İstanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Hospital, İstanbul, Türkiye
2Department of Histology and Embryology, İstanbul University- Cerrahpaşa, Cerrahpaşa Faculty of Medicine, İstanbul, Türkiye
3Department of Biochemistry, University of Health Sciences, İstanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Hospital, İstanbul, Türkiye
4Department of Cardiology, University of Health Sciences, İstanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Hospital, İstanbul, Türkiye

Background: Although energy drinks have been consumed for many years, their effects on the cardiovascular system continue to be investigated. Today, the most frequently used area of energy drinks is the entertainment sector, and this study investigates the
effects of energy drinks and alcohol consumption on rats’ limb and myocardium tissue.
Methods: Forty Wistar Albino rats were used and divided into 4 groups. Energy drinks were given to the first group (the energy drink group), alcohol was given to the second group, and energy drinks and alcohol were given to the third group Redbull-Alcohol (RA). Blood samples, leg muscles, and heart tissues were studied after the ischemia–reperfusion model was created at the infrarenal level.
Results: In the histopathological examination of heart muscles, the damage was significantly more severe in the RA group than in the control group (P <.05). There was no significant change in the RA group in the limb muscle; however, muscle fiber abnormality was higher. The energy drink group was more prone to carbon dioxide retention and hypoxia, resulting in respiratory acidosis. (P =.05). Lactate was significantly higher in the energy drink group (P =.002). Glucose concentrations of energy drink and RA groups were higher (P =.02).
Conclusion: The high lactate values of the energy drink group and more damaged fibers in the striated muscles in the RA group showed that they are more susceptible to ischemia. Long-term energy drinks and alcohol use may cause damage to the heart muscle and endothelium. Also, the effects of long-term alcohol and energy drink use on the respiratory system should be investigated with more specific studies.

Keywords: Energy drinks, ischemia–reperfusion, alcohol, rat

Aylin Demirel, Serdar Başgöze, Kübra Çakıllı, Ünal Aydın, Gözde Erkanlı Şentürk, Vesile Örnek Diker, Mehmet Ertürk. Histopathological Changes in the Myocardium Caused by Energy Drinks and Alcohol in the Mid-term and Their Effects on Skeletal Muscle Following Ischemia-reperfusion in a Rat Model. Anatol J Cardiol. 2023; 27(1): 12-18

Corresponding Author: Aylin Demirel
Manuscript Language: English


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