ISSN 2149-2263 | E-ISSN 2149-2271
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Digital Health Interventions in Patient Management Following Acute Coronary Syndrome: A Meta-Analysis of the Literature [Anatol J Cardiol]
Anatol J Cardiol. 2023; 27(1): 2-9 | DOI: 10.14744/AnatolJCardiol.2022.2254

Digital Health Interventions in Patient Management Following Acute Coronary Syndrome: A Meta-Analysis of the Literature

Faysal Şaylık1, Tufan Çınar2, Mert İlker Hayıroğlu3, Ahmet İlker Tekkeşin4
1Department of Cardiology, Van Training and Research Hospital, Van, Türkiye
2Department of Cardiology, Sultan II. Abdulhamid Han Training and Research Hospital, İstanbul, Türkiye
3Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, İstanbul, Türkiye
4Department of Cardiology, Başakşehir Çam and Sakura City Hospital, İstanbul, Türkiye

Objective: Acute coronary syndrome patients should be closely followed-up to maintain
optimal adherence to medical treatments and to reduce adverse events. Digital health
interventions might provide improved outcomes for patient care by providing closer follow-
up, compared to standard care. Thus, in this meta-analysis, we aimed to evaluate the
effect of digital health interventions on follow-up in acute coronary syndrome patients.
Methods: We searched medical databases to obtain all relevant studies comparing digital
health interventions with standard care in acute coronary syndrome patients. After
reviewing all eligible studies, a meta-analysis was conducted with the remaining 11 randomized
controlled studies and 2 non-randomized controlled studies. A modified Jadad
scale and Newcastle-Ottawa scale were used to assess the quality of the publications
for randomized controlled studies and non-randomized controlled studies, respectively.
Results: This meta-analysis consisted of 7657 patients. The all-cause mortality rate was
49% lower in the digital health intervention cases, compared to those who received standard
care [relative risk (RR) = 0.51 (0.37; 0.70), P <.01]. There was a significant decrease in
systolic blood pressure in the digital health interventions group, compared to the standard
care group [mean difference = -5.28 (-9.47; -1.08), P =.01]. The rate of nonadherence
to anti-aggregant drugs was 69% lower in the digital health interventions than in the
standard care group [RR = 0.31 (0.20; 0.46), P <.01]. Also, nonadherence rates for statin
and beta-blockers were lower in the digital health interventions group. The risk of rehospitalization
was observed to be 55% less in the digital health interventions patients, compared
to the standard care group [RR = 0.45 (0.30; 0.67), P <.01].
Conclusion: Digital health interventions can be effective in follow-up for secondary prevention
in acute coronary syndrome patients.

Keywords: Acute coronary syndrome, digital health intervention, meta-analysis, standard care

Faysal Şaylık, Tufan Çınar, Mert İlker Hayıroğlu, Ahmet İlker Tekkeşin. Digital Health Interventions in Patient Management Following Acute Coronary Syndrome: A Meta-Analysis of the Literature. Anatol J Cardiol. 2023; 27(1): 2-9

Corresponding Author: Tufan Çınar
Manuscript Language: English


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