ISSN 2149-2263 | E-ISSN 2149-2271
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Over-expression of IL1R2 in PBMCs of Patients with Coronary Artery Disease and Its Clinical Significance [Anatol J Cardiol]
Anatol J Cardiol. 2022; 26(9): 710-716 | DOI: 10.5152/AnatolJCardiol.2022.1241

Over-expression of IL1R2 in PBMCs of Patients with Coronary Artery Disease and Its Clinical Significance

Qiang Chen1, Zhenlong Li2, Manman Wang1, Guangping Li1
1Department of Cardiology, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China
2Department of Cardiology, Tianjin Haibin People's Hospital, Tianjin, China

Background: IL-1 has been widely explored and played a role in regulating inflammatory and immune responses to various disorders. Nevertheless, the role of interleukin-1 receptor type II, a protein-coding gene of interleukin-1 in coronary artery disease patients with peripheral blood mononuclear cells, persists to be undetermined.

Methods: Our study discovered the IL-1 receptor type II expression through gene expression omnibus (GEO) public repository based on bioinformatics tools and further validation was carried out between coronary artery disease patients and healthy participants using peripheral blood mononuclear cells samples in Second Hospital of Tianjin Medical University. A total of 180 participants, comprising 90 cases of coronary artery disease and 90 samples of healthy control were retrospectively evaluated and the correlation of IL-1 receptor type II was observed between serum levels of oxidized low-density lipoprotein and SYNTAX score. Furthermore, the clinical significance of IL-1 receptor type II was evaluated in peripheral blood mononuclear cells of coronary artery disease patients by the receiver operating curve using the area under the curve.

Results: IL-1 receptor type II was markedly overexpressed in peripheral blood mononuclear cells and severe patients with coronary artery disease compared to the healthy control participants. Meanwhile, a positive correlation of IL-1 receptor type II expression was significantly observed between SYNTAX score and oxidized low-density lipoprotein of coronary artery disease patients. Further, the receiver operating curve achieved a significantly higher area under the curve of 0.813 in coronary artery disease patients with peripheral blood mononuclear cells. Thus, IL-1 receptor type II expressions were not only directly correlated with peripheral blood mononuclear cells but also showed potential significance in coronary artery disease patients.

Conclusion: IL-1 receptor type II might be involved in the immune/inflammatory responses of coronary artery disease accompanied by other cytokine receptor genes.

Keywords: Coronary artery disease, cytokines, IL1R2, PBMCs, receptor

Qiang Chen, Zhenlong Li, Manman Wang, Guangping Li. Over-expression of IL1R2 in PBMCs of Patients with Coronary Artery Disease and Its Clinical Significance. Anatol J Cardiol. 2022; 26(9): 710-716

Corresponding Author: Guangping Li
Manuscript Language: English


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