ISSN 2149-2263 | E-ISSN 2149-2271
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Volume : 25 Issue : 4 Year : 2021
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Clinical Analysis of Cardiac Autonomic Ganglion Plexus Ablation for Bradyarrhythmia: Research Protocol for An Intervention Study [Anatol J Cardiol]
Anatol J Cardiol. Ahead of Print: AJC-94797

Clinical Analysis of Cardiac Autonomic Ganglion Plexus Ablation for Bradyarrhythmia: Research Protocol for An Intervention Study

Mingliang Shao, YaoDong Li, Xianhui Zhou, Yanmei Lu, Ling Zhang, Baopeng Tang
Department of Cardiac Pacing and Electrophysiology, Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China

Background: The heart is controlled by its own intrinsic and central autonomic nerves. Increased cardiac vagal tone leads to sinus node dysfunction and atrioventricular conduction disorders, resulting in bradyarrhythmia. Pacemaker implement can relieve the symptoms of arrhythmia caused by bradycardia, but it is not easy for patients to accept. Therefore, more and more attention has been paid to cardiac vagus nerve ablation.
Methods: In this study, 20 patients who met the inclusion criteria of ganglion plexus (GP) ablation in the First Affiliated Hospital of Xinjiang Medical University from November 2019 to June 2020 were enrolled. Biochemical and other related examinations and electrophysiological examinations were conducted before ablation, and then cardiac GP ablation was performed. The patients were followed up 3 times at 3, 6 and 12 months after operation.
Discussion: Cardiac GP ablation is relatively simple and easy to implement in units that have performed radiofrequency ablation for tachyarrhythmias. This technology can be done without any new equipment. At least some patients with bradycardia may not have a permanent pacemaker implantation and have additional treatment options.
Ethics and dissemination: This study protocol was approved by the Institutional Review Board of the First Affiliated Hospital of Xinjiang Medical University (Approval number: 20180622-09). Findings will be published in peer-reviewed journals and communicated in cardiovascular conferences.
Trial registration: Chinese Clinical Trial Registry, ChiCTR1900027305. Registered on 8 November 2019. chictr.org.cn.

Keywords: bradyarrhythmia, ganglion plexus ablation, research protocol



Corresponding Author: Baopeng Tang, China