ISSN 2149-2263 | E-ISSN 2149-2271
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Systemic Immune-Inflammatory Index Is Associated with Residual SYNTAX Score in Patients with ST-Segment Elevation Myocardial Infarction [Anatol J Cardiol]
Anatol J Cardiol. 2023; 27(8): 472-478 | DOI: 10.14744/AnatolJCardiol.2023.3074

Systemic Immune-Inflammatory Index Is Associated with Residual SYNTAX Score in Patients with ST-Segment Elevation Myocardial Infarction

Mehmet Altunova1, Muammer Karakayalı2, Serkan Kahraman1, Yalçın Avcı1, Gökhan Demirci1, Samet Sevinç1, Serkan Yazan1, Anıl Şahin3, Mehmet Ertürk1
1Department of Cardiology, University of Health Sciences, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, İstanbul, Turkey
2Department of Cardiology, Faculty of Medicine, Kafkas University, Kars, Turkey
3Department of Cardiology, Faculty of Medicine, İstinye University, Liv Bahçeşehir Hospital, İstanbul, Turkey

Background: Systemic immune-inflammatory index (platelet count × neutrophil–lymphocyte ratio) is a new marker that predicts adverse clinical outcomes in coronary artery diseases. Our aim was to investigate the relationship between the systemic immune-inflammatory index and residual SYNTAX score in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.

Methods: In this retrospective study, 518 consecutive patients who underwent primary percutaneous coronary intervention (PCI) with the diagnosis of ST-segment elevation myocardial infarction were analyzed. The severity of coronary artery diseases was determined by residual SYNTAX score. In the receiver operating characteristic curve analysis, systemic immune-inflammatory index with an optimal threshold value of 1025.1 could detect the presence of a high residual SYNTAX score; the patients were divided into 2 groups as low (326) and high (192) according to the threshold value. In addition, binary multiple logistic regression analysis methods were used to evaluate independent predictors of high residual SYNTAX score.

Results: In binary multiple logistic regression analysis, systemic immune-inflammatory index [odds ratio = 6.910; 95% CI = 4.203-11.360; P <.001] was an independent predictor of high residual SYNTAX score. In addition, there was a positive correlation between the systemic immune-inflammatory index and residual SYNTAX score (r = 0.350, P <.001). In the receiver operating characteristic curve analysis, the systemic immune-inflammatory index with an optimal threshold value of 1025.1 could detect the presence of a high residual SYNTAX score with 73.8% sensitivity and 72.3% specificity.

Conclusion: Systemic immune-inflammatory index, an inexpensive and easily measurable laboratory variable, was an independent predictor of the increased residual SYNTAX score in patients with ST-segment elevation myocardial infarction.

Keywords: Coronary artery disease, residual SYNTAX score, systemic immune-inflammatory index

Mehmet Altunova, Muammer Karakayalı, Serkan Kahraman, Yalçın Avcı, Gökhan Demirci, Samet Sevinç, Serkan Yazan, Anıl Şahin, Mehmet Ertürk. Systemic Immune-Inflammatory Index Is Associated with Residual SYNTAX Score in Patients with ST-Segment Elevation Myocardial Infarction. Anatol J Cardiol. 2023; 27(8): 472-478

Corresponding Author: Mehmet Altunova
Manuscript Language: English


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