ISSN 2149-2263 | E-ISSN 2149-2271
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Volume : 25 Issue : 4 Year : 2021
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Characteristics of organ cysts and their association with type A aortic dissection [Anatol J Cardiol]
Anatol J Cardiol. 2021; 25(4): 236-242 | DOI: 10.14744/AnatolJCardiol.2020.99537

Characteristics of organ cysts and their association with type A aortic dissection

Yao-Jun Dun, Hong-wei Guo, Yi Chang, Ke Wei, Shu-Ya Fan, Xiao-Gang Sun, Xiang-yang Qian, Cun-tao Yu
Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College; Beijing-China

Objective: We aimed to evaluate the incidence of organ cysts in patients with type A aortic dissection (TAAD) to assess the association between organ cysts and TAAD.
Methods: Between January 2018 and December 2018, all patients with TAAD undergoing aortic surgery at our center were enrolled into the study; patients undergoing isolated coronary artery bypass grafting at our center were selected as the control group. Baseline differences between the 2 groups were adjusted using propensity-score matching. The incidence of organ cysts was compared between the 2 groups in total and matched cohorts.
Results: We enrolled 290 patients with TAAD and 293 patients with coronary artery disease (control group). The incidence of all organ cysts, liver cysts, renal cysts, and other organ cysts, was significantly higher in the TAAD group than in the control group (50.0% vs. 35.5%, p<0.001; 24.5% vs. 10.2%, p<0.001; 33.4% vs. 24.9%, p=0.023; and 6.2% vs. 1.5%, p=0.005; respectively). Among the 191 propensity score–matched patient pairs, the incidence of organ cysts, liver cysts, renal cysts, and other organ cysts was also significantly higher in the TAAD group than in the control group (57.6% vs. 30.9%, p<0.001; 28.8% vs. 11.0%, p<0.001; 39.3% vs. 19.9%, p<0.001; and 8.4% vs. 1.0%, p=0.001; respectively). The incidence of cysts with single-organ and multiple-organ involvement was also significantly higher in the TAAD group than in the control group (34.0% vs. 20.4%, p=0.003; and 23.6% vs. 10.5%, p=0.001).
Conclusion: Our results show a higher incidence of organ cysts in patients with TAAD which is indicative of a common pathogenetic pathway between organ cysts and aortic dissection.

Keywords: Organ cyst, pathogenesis, renal cyst, aortic dissection

Yao-Jun Dun, Hong-wei Guo, Yi Chang, Ke Wei, Shu-Ya Fan, Xiao-Gang Sun, Xiang-yang Qian, Cun-tao Yu. Characteristics of organ cysts and their association with type A aortic dissection. Anatol J Cardiol. 2021; 25(4): 236-242

Corresponding Author: Hong-wei Guo, China