ISSN 2149-2263 | E-ISSN 2149-2271
Volume : 26 Issue : 1 Year : 2022
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The Anatolian Journal of Cardiology Change in pulmonary arterial compliance and pulmonary pulsatile stress after balloon pulmonary angioplasty [Anatol J Cardiol]
Anatol J Cardiol. 2022; 26(1): 43-48 | DOI: 10.5152/AnatolJCardiol.2021.149

Change in pulmonary arterial compliance and pulmonary pulsatile stress after balloon pulmonary angioplasty

Dursun Akaslan1, Halil Ataş1, Emre Aslanger1, Batur Gönenç Kanar1, Derya Kocakaya2, Bedrettin Yıldızeli3, Bülent Mutlu1
1Department of Cardiology, Marmara University, Pendik Training and Research Hospital; İstanbul-Turkey
2Department of Pulmonology, Marmara University, Pendik Training and Research Hospital; İstanbul-Turkey
3Department of Thoracic Surgery, Marmara University, Pendik Training and Research Hospital; İstanbul-Turkey

Objective: Although the underlying pathology of chronic thromboembolic pulmonary hypertension (CTEPH) is mechanical obliteration of the major pulmonary vessels, high pulsatile stress penetrating into the normal distal pulmonary microvasculature resulting from reduced pulmonary arterial compliance (CPA) may cause progressive deterioration in pulmonary hemodynamics. Hypothetically, balloon pulmonary angioplasty (BPA) may be beneficial in reducing CPA and pulsatile stress in patients with CTEPH.
Methods: In total, 26 patients with available pre- and post-BPA right heart catheterization results were included in the study. BPA was performed in a series of staged procedures by 2 experienced interventional cardiologists.
Results: The median CPA showed a 59.2% increase (1.03 to 1.64 mL/mm Hg, p=0.005). The median pre-BPA pulsatile stress product decreased by 20.7% (4,266 to 3,380 mm Hg/min, p=0.003). A linear regression model established that the percent change in CPA after BPA accounted for 21.8% of the explained variability in the change in 6-minute walk test (p=0.009).
Conclusion: Our results indicate that BPA decreases CPA and pulmonary pulsatile stress. These changes may be partly responsible for the improvement in functional capacity after BPA.

Keywords: balloon angioplasty, compliance, pulmonary embolism, pulmonary hypertension, pulsatile flow

Dursun Akaslan, Halil Ataş, Emre Aslanger, Batur Gönenç Kanar, Derya Kocakaya, Bedrettin Yıldızeli, Bülent Mutlu. Change in pulmonary arterial compliance and pulmonary pulsatile stress after balloon pulmonary angioplasty. Anatol J Cardiol. 2022; 26(1): 43-48

Corresponding Author: Dursun Akaslan, Türkiye
Manuscript Language: English