ISSN 2149-2263 | E-ISSN 2149-2271
The Anatolian Journal of Cardiology
Impact of early (3 months) dual antiplatelet treatment interruption prior to renal transplantation in patients with second-generation DES on perioperative stent thrombosis and MACEs [Anatol J Cardiol]
Anatol J Cardiol. 2017; 18(6): 391-396 | DOI: 10.14744/AnatolJCardiol.2017.7885

Impact of early (3 months) dual antiplatelet treatment interruption prior to renal transplantation in patients with second-generation DES on perioperative stent thrombosis and MACEs

Ali Doğan1, Emrah Özdemir1, Serkan Kahraman2, Tayfun Açıl1, Yelda Saltan1, Nuri Kurtoğlu1
1Department of Cardiology, Gaziosmanpaşa Hospital, Faculty of Medicine, Istanbul Yeni Yüzyıl University, İstanbul-Turkey
2Department of Cardiology, Istanbul Silivri State Hospital, İstanbul-Turkey

Objective: Early cessation of dual antiplatelet therapy (DAPT) is related to stent thrombosis (ST). The use of second-generation everolimus- and zotarolimus-eluting stents is associated with low restenosis rates and short duration of clopidogrel usage. Non-cardiac surgery in recently stent-implanted patients is associated with major adverse cardiac events (MACEs). Chronic renal failure patients awaiting renal transplantation may also undergo coronary stent implantation prior to surgery. Here we aimed to investigate the safety of early (3 months) DAPT interruption in second-generation drug-eluting stent (DES)-implanted renal transplant recipients.
Methods: In total, 106 previously stent-implanted chronic renal failure patients who underwent renal transplantation were retrospectively enrolled. Three groups were formed according to stent type and the duration of DAPT: early-interruption (3 months from DES implantation), lateinterruption (3–12 months from DES implantation), and bare-metal stent (BMS; at least 1 month from BMS implantation) groups.
Results: Comparison among BMS, DES-early and DES-late groups indicated no difference in ST, myocardial infarction, death, and MACEs. In addition, no difference was observed in ST (p=0.998), myocardial infarction (p=0.998), death (p=0.999), and MACEs (p=0.998) between DES-early and DES-late groups.
Conclusion: Early (3 months) interruption of antiplatelet treatment with second-generation stents before renal transplantation seems to be safe and does not lead to increase in the occurrence of ST and MACEs.

Keywords: percutaneous coronary intervention, drug-eluting stents, non-cardiac surgery; stent thrombosis; chronic renal failure

Ali Doğan, Emrah Özdemir, Serkan Kahraman, Tayfun Açıl, Yelda Saltan, Nuri Kurtoğlu. Impact of early (3 months) dual antiplatelet treatment interruption prior to renal transplantation in patients with second-generation DES on perioperative stent thrombosis and MACEs. Anatol J Cardiol. 2017; 18(6): 391-396

Corresponding Author: Ali Doğan, Türkiye
Manuscript Language: English


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