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Volume : 16 Issue : 12 Year : 2021
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The Anatolian Journal of Cardiology Increased serum YKL-40 level is associated with the presence and severity of metabolic syndrome [Anatol J Cardiol]
Anatol J Cardiol. 2016; 16(12): 953-958 | DOI: 10.14744/AnatolJCardiol.2016.6933

Increased serum YKL-40 level is associated with the presence and severity of metabolic syndrome

Mehmet Kadri Akboğa1, Rıdvan Yalçın2, Asife Şahinarslan2, Canan Yılmaz Demirtaş3, Hatice Paşaoğlu3, Adnan Abacı2
1Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital; Ankara-Turkey
2Department of Cardiology, Faculty of Medicine, Gazi University; Ankara-Turkey
3Medical Biochemistry, Faculty of Medicine, Gazi University; Ankara-Turkey

Objective: Metabolic syndrome (MS) is defined by a cluster of interdependent physiological, biochemical, and clinical risk factors and linked to a state of chronic inflammation. YKL-40 is known as an inflammatory glycoprotein, which is secreted by various cell lines during inflammation. Thus, we aimed to assess the association of serum YKL-40 levels with the presence and severity of MS.
Methods: In this prospective cross-sectional study, a total of 177 consecutive patients [n=114 MS present and n=63 MS absent] were enrolled. MS was defined according to National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria. Serum YKL-40 and hs-CRP levels were measured for all participants.
Results: Serum YKL-40, hs-CRP and white blood cell count (WBC) were significantly higher in the MS present group (p<0.05). There was a graded relationship between increasing number of MS components and serum YKL-40 level (p<0.05). In addition, serum YKL-40 level was positively correlated with hs-CRP level (r=0.467, p<0.001) and WBC count (r=0.251, p=0.001). In multivariable regression analysis, serum YKL-40 [1.022 (1.011–1.033), p<0.001] and hs-CRP [1.346 (1.111–1.632), p=0.002] were remained as independent predictors for the presence of MS. In the ROC curve analysis, using a cut-off level of 147.0, YKL-40 well predicted the presence of MS with a sensitivity of 73.7% and specificity of 69.8% (AUC: 0.785; 95% CI: 0.718–0.853, p<0.001).
Conclusion: In this study, we demonstrated that serum YKL-40 level was significantly associated with the presence of MS. According to these findings, we concluded that serum YKL-40 may be a novel and useful indicator for MS. (Anatol J Cardiol 2016; 16: 953-8)

Keywords: metabolic syndrome, cardiovascular risk factors, hs-CRP, YKL-40, infl, ammation

Mehmet Kadri Akboğa, Rıdvan Yalçın, Asife Şahinarslan, Canan Yılmaz Demirtaş, Hatice Paşaoğlu, Adnan Abacı. Increased serum YKL-40 level is associated with the presence and severity of metabolic syndrome. Anatol J Cardiol. 2016; 16(12): 953-958

Corresponding Author: Mehmet Kadri Akboğa, Türkiye