ISSN 2149-2263 | E-ISSN 2149-2271
The Anatolian Journal of Cardiology
The Effects of Handgrip Stress Test on Hemodynamic Parameters Before and After Cilazapril Treatment in Patients with Heart Failure [Anatol J Cardiol]
Anatol J Cardiol. 2003; 3(1): 38-42

The Effects of Handgrip Stress Test on Hemodynamic Parameters Before and After Cilazapril Treatment in Patients with Heart Failure

Talat Tavlı1, Hakan Göçer2
1Department of Cardiology, Celal Bayar University, School of Medicine, Manisa, Turkey
2Celal Bayar Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Manisa

Objective: To assess the effect of cilazapril treatment on several hemodynamic parameters during handgrip maneuvers in patients with congestive heart failure. Cilazapril, an ACE inhibitor with high affinity, has been shown to be highly effective against a variety of vascular disorders. The effectiveness of isometric handgrip exercise on changes of cardiovascular hemodynamic parameters before and after cilazapril treatment in patients with congestive heart failure is unknown. Methods: The study population included 30 patients (16 male, 14 female) with mean age of 65±18 years. The effects of handgrip maneuver on hemodynamic parameters were studied by right heart catheterization and Doppler echocardiography. Results: Heart rate (HR) and mean arterial pressures (MAP) increased significantly after handgrip maneuver (from 95±6 beats/min to 101±12 beats/min; from 109±15 mm Hg to 118±19 mm Hg, p<0.05 respectively). Pulmonary capillary wedge pressure (PCWP), pulmonary artery systolic (s) and diastolic (d) pressures (PAP), cardiac index (CI), right ventricular systolic and diastolic pressures (RVPs and RVPd), left ventricular ejection fraction (LVEF), right ventricular ejection fraction (RVEF) did not change after handgrip maneuvers (p>0.05). On the other hand, PAPs and PAPd, RVPs and RVPd, MAP and HR (p<0.05) decreased significantly during handgrip maneuvers after cilazapril treatment. However PCWP and CI, LVEF, RVEF did not change after treatment (p>0.05). Conclusion: Cardiovascular response to handgrip maneuver may be a marker of failure to respond to compensatory mechanisms. Cilazapril treatment was associated with significant improvement in hemodynamic parameters during handgrip stress test, the mechanisms of which are increased sympathetic and renin-angiotensin system activation, and altered vascular tonus.

Keywords: Handgrip maneuver, heart failure, hemodynamic parameters

Talat Tavlı, Hakan Göçer. The Effects of Handgrip Stress Test on Hemodynamic Parameters Before and After Cilazapril Treatment in Patients with Heart Failure. Anatol J Cardiol. 2003; 3(1): 38-42
Manuscript Language: English


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