ISSN 2149-2263 | E-ISSN 2149-2271
The Anatolian Journal of Cardiology
Ischemic Preconditioning [Anatol J Cardiol]
Anatol J Cardiol. 2003; 3(2): 144-149

Ischemic Preconditioning

Harun Evrengül1, Dursun oğlu2, Ender Semiz3
1Pamukkale Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı, Denizli, Türkiye
2Pamukkale Üniversitesi Tıp Fakültesi Kardiyoloji, Anabilim Dalı, Denizli
3Pamukkale Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Denizli

Summary: It has been shown that repeated brief coronary occlusions increase myocardial resistance towards prolonged episodes of ischemia. This phenomenon, which renders the heart more tolerant to ischemia with subsequent limitation of infarct size, has been termed ischemic preconditioning. Ischemic preconditioning also protects the heart against postinfarction left ventricular dysfunction and ventricular arrhythmias. Ischemia induced activation of adenosine receptors, and opening of ATP-sensitive potassium channels and stress protein synthesis are thought to be the potential mechanisms of this phenomenon. The exploration of the exact mechanisms of ischemic preconditioning might improve the treatment strategies for acute myocardial infarction in the future.

Keywords: İskemik önkoşullanma, akut miyokard infarktüsü, kartiyoproteksiyon

Harun Evrengül, Dursun oğlu, Ender Semiz. Ischemic Preconditioning. Anatol J Cardiol. 2003; 3(2): 144-149
Manuscript Language: English

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