ISSN 2149-2263 | E-ISSN 2149-2271
The Anatolian Journal of Cardiology
Relationship of activin A levels with clinical presentation, extent, and severity of coronary artery disease [Anatol J Cardiol]
Anatol J Cardiol. 2017; 18(6): 402-409 | DOI: 10.14744/AnatolJCardiol.2017.7935

Relationship of activin A levels with clinical presentation, extent, and severity of coronary artery disease

Nadia Bouzidi1, Fethi Betbout2, Faouzi Maatouk3, Habib Gamra2, Abdelhedi Miled1, Salima Ferchichi1
1Department of Faculty of Pharmacy, Clinical and molecular biology unit (UR 17ES29), University of Monastir, Tunisia
2Department of Cardiology A Department Fattouma Bourguiba University Hospital-Cardiothrombosis Research Laboratory (LR12SP16), Tunisia
3Department of Cardiology B Department, Fattouma Bourguiba University Hospital of Monastir, Tunisia

Objective: We aimed to evaluate the relationship of serum activin A levels with risk factors, clinical presentation, biochemical marker levels, extent, and severity of atherosclerotic coronary artery disease (CAD).
Methods: In total, 310 CAD patients [92 with ST-segment elevation myocardial infarction (STEMI), 111 with non-STEMI (NSTEMI), and 107 with unstable angina (UA)] and 207 healthy subjects (controls) were enrolled. Activin A levels in all participants were measured using ELISA. Angiographic measurements were performed in patients and not in the healthy subjects.
Results: Activin A levels were higher in all patient groups than in controls (patients vs. controls, p=0.041; NSTEMI vs. UA, p=0.744; STEMI vs. UA, p=0.172; NSTEMI vs. STEMI, p=0.104). According to the cut-off value of activin A level, patients with high and low activin A levels had a similar distribution of clinical and biochemical variables but the prevalence of severe stenosis was observed in groups with high activin A levels. Our results revealed that activin A levels did not decrease as thrombolysis in myocardial infarction (risk score increased (p=0.590). The area under the ROC curve for activin A levels in patients was 0.590±0.047 (95% CI: 0.439–0.591, p=0.193). In multiple analysis of the overall population, male gender (β=–0.260; 95% CI: –617.39 to –110.04; p=0.005) was an independent predictor of activin A levels.
Conclusion: This study indicated that activin A can not be a predictive marker in CAD and is not associated with extensive and severe CAD. In contrast, the increase in activin A levels in patients, especially in patients with different clinical groups of acute coronary syndromes, suggested its involvement in atherosclerosis.

Keywords: Activin A, coronary artery disease, risk factors, extent, severity

Nadia Bouzidi, Fethi Betbout, Faouzi Maatouk, Habib Gamra, Abdelhedi Miled, Salima Ferchichi. Relationship of activin A levels with clinical presentation, extent, and severity of coronary artery disease. Anatol J Cardiol. 2017; 18(6): 402-409

Corresponding Author: Nadia Bouzidi, Tunisia
Manuscript Language: English


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