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The Anatolian Journal of Cardiology Short-term effect of nebivolol on the left ventricular diastolic function [Anatol J Cardiol]
Anatol J Cardiol. 2004; 4(4): 323-326

Short-term effect of nebivolol on the left ventricular diastolic function

Ergün Demiralp1, Ejder Kardeşoğlu2, Turgay Çelik3, Bekir Sıtkı Cebeci2, Namık Özmen2, Zafer Işılak1, Rıfat Eralp Ulusoy7, Mehmet Dinçtürk8
1Gülhane Askeri Tıp Akademisi, Haydarpaşa Eğitim Hastanesi, Kardiyoloji Servisi, İstanbul
2Department of Cardiology, GATA Haydarpaşa Education Hospital, Kadıköy, İstanbul, Turkey
3Department of Cardiology School of Medicine, Gülhane Military Medical Academy, Etlik, Ankara
4Department of Cardiology, GATA Haydarpaşa Education Hospital, Kadıköy, İstanbul, Turkey
5Department of Cardiology, GATA Haydarpaşa Education Hospital, Kadıköy, İstanbul, Turkey
6Gülhane Askeri Tıp Akademisi, Haydarpaşa Eğitim Hastanesi, Kardiyoloji Servisi, İstanbul
7Cardiology Section, GATA Haydarpaşa Teaching Hospital, Üsküdar, İstanbul, Turkey
8GATA Haydarpaşa Eğitim Hastanesi, Kardiyoloji Servisi, İstanbul, Türkiye

Objective: To determine the effects of nebivolol on diastolic functions of the left ventricle in the hypertensive patients in the early treatment period. Methods: Twenty patients with mild to moderate hypertension taking daily 5 mg of nebivolol were assessed by using Doppler echocardiography before and after 6-week drug treatment period. The results were analyzed with Wilcoxon test and p<0.05 was accepted as statistically significant value. Results: The arterial blood pressure and heart rate of the patients significantly decreased after 6 weeks of treatment. Statistically significant decrease was found in the peak of A wave velocity, isovolumetric relaxation time, E wave deceleration time and increase in E/A ratio with Doppler echocardiography after 6-week treatment period. No statistically significant difference was observed in the peak velocity of E wave after treatment period. Conclusion: We found that nebivolol improved left ventricle diastolic function in patients with hypertension in the early term.

Keywords: Nebivolol, hypertension, left ventricle diastolic functions

Nebivololün sol ventrikül diyastolik fonksiyonları üzerine erken dönem etkisi

Ergün Demiralp1, Ejder Kardeşoğlu2, Turgay Çelik3, Bekir Sıtkı Cebeci2, Namık Özmen2, Zafer Işılak1, Rıfat Eralp Ulusoy7, Mehmet Dinçtürk8
1Gülhane Askeri Tıp Akademisi, Haydarpaşa Eğitim Hastanesi, Kardiyoloji Servisi, İstanbul
2Department of Cardiology, GATA Haydarpaşa Education Hospital, Kadıköy, İstanbul, Turkey
3Department of Cardiology School of Medicine, Gülhane Military Medical Academy, Etlik, Ankara
4Department of Cardiology, GATA Haydarpaşa Education Hospital, Kadıköy, İstanbul, Turkey
5Department of Cardiology, GATA Haydarpaşa Education Hospital, Kadıköy, İstanbul, Turkey
6Gülhane Askeri Tıp Akademisi, Haydarpaşa Eğitim Hastanesi, Kardiyoloji Servisi, İstanbul
7Cardiology Section, GATA Haydarpaşa Teaching Hospital, Üsküdar, İstanbul, Turkey
8GATA Haydarpaşa Eğitim Hastanesi, Kardiyoloji Servisi, İstanbul, Türkiye

Anahtar Kelimeler: Nebivolol, hipertansiyon, sol ventrikül diyastolik fonksiyonları

Ergün Demiralp, Ejder Kardeşoğlu, Turgay Çelik, Bekir Sıtkı Cebeci, Namık Özmen, Zafer Işılak, Rıfat Eralp Ulusoy, Mehmet Dinçtürk. Short-term effect of nebivolol on the left ventricular diastolic function. Anatol J Cardiol. 2004; 4(4): 323-326
Manuscript Language: English