ISSN 2149-2263 | E-ISSN 2149-2271
Volume : 4 Issue : 4 Year : 2021
Quick Search



The Anatolian Journal of Cardiology Effects of enalaprilat infusion on hemodynamics and renal function in patients undergoing cardiac surgery [Anatol J Cardiol]
Anatol J Cardiol. 2004; 4(4): 296-300

Effects of enalaprilat infusion on hemodynamics and renal function in patients undergoing cardiac surgery

Handan Türker1, Aslı Dönmez2, Pınar Zeyneloğlu3, Atilla Sezgin4, Melek Uluçam5
1Department of Anesthesiology Surgery University of Baskent, School of Medicine, Ankara, Turkey
2Clinic of Anesthesiology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara-Turkey
3Department of Anesthesiology, Faculty of Medicine, Başkent University, Ankara, Turkey
4Department of Cardiothoracic and Vascular Surgery University of Baskent, School of Medicine, Ankara, Turkey
5Başkent Üniversitesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye

Objective: This study was undertaken to evaluate the effect of Enalaprilat infusion on hemodynamics and renal function during cardiopulmonary bypass (CPB). Methods: Thirty adults undergoing CPB were randomly allocated into 2 groups. All patients received the same anesthetic protocol and same dopamine infusion protocol (2 mg/kg -1/min-1) during the study. In addition to dopamine infusion 15 patients received enalaprilat infusion (0.06 mg/kg-1/hr-1) during CPB. Blood creatinine, urea levels, and creatinine clearance (CLcr) were measured and cardiac output (CO) was calculated by echocardiography preoperatively and on the 6th postoperative day. Mean arterial pressure (MAP), central venous pressure (CVP), systemic vascular resistance (SVR) measurements were recorded during the operation and during postoperative 24 hours. Results: In the control group postoperative blood creatinine and urea levels were significantly higher and CLcr measurements were significantly lower than the preoperative values (p<0.05). These values did not change in the enalaprilat group. Mean arterial pressure was similar in both groups (p>0.05), but SVR was lower (p<0.05) and CVP was higher (p<0.05) in the enalaprilat group than in the control group. In the enalaprilat group postoperative CO measurements were higher than the preoperative values (p<0.05). Conclusion: Our results demonstrate that enalaprilat infusion during CPB improves renal function and CO measurements in the early postoperative period.

Keywords: Cardiopulmonary bypass, enalaprilat, renal function, hemodynamics

Kalp cerrahisinde kullanılan enalaprilat infüzyonunun hemodinamik değişkenlere ve böbrek fonksiyonlarına etkisi

Handan Türker1, Aslı Dönmez2, Pınar Zeyneloğlu3, Atilla Sezgin4, Melek Uluçam5
1Department of Anesthesiology Surgery University of Baskent, School of Medicine, Ankara, Turkey
2Clinic of Anesthesiology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara-Turkey
3Department of Anesthesiology, Faculty of Medicine, Başkent University, Ankara, Turkey
4Department of Cardiothoracic and Vascular Surgery University of Baskent, School of Medicine, Ankara, Turkey
5Başkent Üniversitesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye

Anahtar Kelimeler: Kardiyopulmoner baypas, enalaprilat, böbrek fonksiyonları, hemodinami

Handan Türker, Aslı Dönmez, Pınar Zeyneloğlu, Atilla Sezgin, Melek Uluçam. Effects of enalaprilat infusion on hemodynamics and renal function in patients undergoing cardiac surgery. Anatol J Cardiol. 2004; 4(4): 296-300
Manuscript Language: English