ISSN 2149-2263 | E-ISSN 2149-2271
The Anatolian Journal of Cardiology
Adherence to Current Dyslipidemia Guideline in Patients Utilizing Statins According to Risk Groups and Gender Differences: The AIZANOI Study [Anatol J Cardiol]
Anatol J Cardiol. 2024; 28(6): 273-282 | DOI: 10.14744/AnatolJCardiol.2024.4218

Adherence to Current Dyslipidemia Guideline in Patients Utilizing Statins According to Risk Groups and Gender Differences: The AIZANOI Study

Taner Şen1, Lale Dinç asarcıklı2, Saadet Güven3, Umut Kocabaş4, Mehmet Özgeyik5, Mevlüt Demir1, Tülay Oskay6, Halil İbrahim  Durmuş7, Belma Kalaycı8, Muhammet Cihat  Çelik9, Fatih Kahraman7, Ökkeş Utku7, Mehmet Ali  Astarcıoğlu1, Sabiye Yılmaz1, Abdullah Tunçez10
1Department of Cardiology, Faculty of Medicine, Kütahya Health Sciences University, Kütahya, Türkiye
2Department of Cardiology, Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Center, İstanbul, Türkiye
3Department of Cardiology, İstanbul Training and Research Hospital, İstanbul, Türkiye
4Department of Cardiology, Başkent University İzmir Hospital, İzmir, Türkiye
5Department of Cardiology, Eskişehir City Hospital, Eskişehir, Türkiye
6Department of Cardiology, Burdur Bucak State Hospital, Burdur, Türkiye
7Department of Cardiology, Kütahya Evliya Çelebi Training and Research Hospital, Kütahya, Türkiye
8Department of Cardiology, Zonguldak Bülent Ecevit University, Faculty of Medicine, Zonguldak, Türkiye
9Department of Cardiology, Çorum Training and Research Hospital, Çorum, Türkiye
10Department of Cardiology, Faculty of Medicine, Konya Selçuk University, Konya, Türkiye

Background: The aim of this study was to assess the adherence to the current European Society of Cardiology dyslipidemia guidelines, the ratio of reaching target values according to risk groups, and the reasons for not reaching LDL-cholesterol (LDL-C) goals in patients on already statin therapy in a cardiology outpatient population.

Methods: The AIZANOI study is a multi-center, cross-sectional observational study including conducted in 9 cardiology centers between August 1, 2021, and November 1, 2021.

Results: A total of 1225 patients (mean age 62 ± 11 years, 366 female) who were already on statin therapy for at least 3 months were included. More than half (58.2%) of the patients were using high-intensity statin regimens. Only 26.2% of patients had target LDL-C level according to their risk score. Despite 58.4% of very high-risk patients and 44.4% of high-risk patients have been using a high-intensity statin regimen, only 24.5% of very-high-risk patients and only 34.9% of high-risk patients have reached guideline-recommended LDL-C levels. Most prevalent reason for not using target dose statin was physician preference (physician inertia) (40.3%).

Conclusion: The AIZANOI study showed that we achieved a target LDL-C level in only 26.2% of patients using statin therapy. Although 58.4% of patients with a very high SCORE risk and 44.4% of patients with a high SCORE risk were using a target dose statin regimen, we were only able to achieve guideline-recommended LDL-C levels in 24.5% and 34.9% of them, respectively, in cardiology outpatients clinics. Physician inertia is one of the major factors in non-adherence to guidelines. These findings highlight that combination therapy is needed in most of the patients.

Keywords: Low-density lipoprotein cholesterol, statins, SCORE risk

Taner Şen, Lale Dinç asarcıklı, Saadet Güven, Umut Kocabaş, Mehmet Özgeyik, Mevlüt Demir, Tülay Oskay, Halil İbrahim  Durmuş, Belma Kalaycı, Muhammet Cihat  Çelik, Fatih Kahraman, Ökkeş Utku, Mehmet Ali  Astarcıoğlu, Sabiye Yılmaz, Abdullah Tunçez. Adherence to Current Dyslipidemia Guideline in Patients Utilizing Statins According to Risk Groups and Gender Differences: The AIZANOI Study. Anatol J Cardiol. 2024; 28(6): 273-282

Corresponding Author: Taner Şen, Türkiye
Manuscript Language: English


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