ISSN 2149-2263 | E-ISSN 2149-2271
Volume : 19 Issue : 1 Year : 2021
Quick Search

The Anatolian Journal of Cardiology Neuroprotective effect of selective antegrade cerebral perfusion during prolonged deep hypothermic circulatory arrest: Cerebral metabolism evidence in a pig model [Anatol J Cardiol]
Anatol J Cardiol. 2018; 19(1): 2-10 | DOI: 10.14744/AnatolJCardiol.2017.7946

Neuroprotective effect of selective antegrade cerebral perfusion during prolonged deep hypothermic circulatory arrest: Cerebral metabolism evidence in a pig model

Zhixian Tang1, Mengya Liang2, Guangxian Chen2, Jian Rong3, Jianping Yao2, Zhen Chen3, Xiao Yang2, Zhongkai Wu2
1Department of Cardiothoracic Surgery, The First Affiliated Hospital of Gannan Medical University; Ganzhou-China
2Department of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-Sen University; Guangzhou-China
3Department of Anesthesiology, The First Affiliated Hospital of Sun Yat-Sen University; Guangzhou-China

Objective: The aim of this study was to elucidate the mechanism of cerebral injury and to evaluate selective antegrade cerebral perfusion (SACP) as a superior neuroprotective strategy for prolonged deep hypothermic circulatory arrest (DHCA).
Methods: Twelve pigs (6–8-week old) were randomly assigned to DHCA alone (n=6) and DHCA with SACP (n=6) at 18°C for 80 min groups. Serum S100 was determined using an immunoassay analyzer. The concentrations of cerebral dialysate glucose, lactate, pyruvate, glycerol, and glutamate were measured using a microdialysis analyzer.
Results: Compared with a peak at T4 (after 60 min of rewarming) in the DHCA group, the serum S100 in the SACP group was significantly lower throughout the study. The DHCA group was susceptible to significant increases in the levels of lactate, glycerol, and glutamate and the ratio of lactate/pyruvate as well as decreases in the level of glucose. These microdialysis variables showed only minor changes in the SACP group. There was a positive correlation between cerebral lactate and intracranial pressure during reperfusion in the DHCA group. However, the apoptosis index and C-FOS protein levels were lower in the SACP group.
Conclusion: Metabolic dysfunction is involved in the mechanism of cerebral injury. SACP is a superior neuroprotective strategy for both mild and prolonged DHCA.

Keywords: DHCA, SACP, cerebral injury, neuroprotective strategy, microdialysis, metabolism

Full Text

ISSN 2149-2263 | E-ISSN 2149-2271

Impact Factor: 1.596
5-Year Impact Factor: 1.623
Eigenfactor Score: 0.001940
CiteScore: 2.1
Source Normalized Impact
per Paper: 0.39
SCImago Journal Rank: 0.39

Volume : 25 Issue : 9 Year : 2021
Quick Search
The Anatolian Journal of Cardiology The Anatolian Journal of Cardiology - Anatol J Cardiol: 25 (9)
Volume: 25  Issue: 9 - September 2021
1.Thrombosis in COVID-19: We still need to learn a lot
Cem Barçın
doi: 10.5152/AnatolJCardiol.2021.9  Page 600
Abstract | Full Text PDF

2.Thrombosis, an important piece in the COVID-19 puzzle: From pathophysiology to therapy
Elena Bobescu, Luigi Geo Marceanu, Alexandru Covaciu, Larisa Alexandra Vladau
doi: 10.5152/AnatolJCardiol.2021.475  Pages 601 - 608

3.Incidence of atrial fibrillation and its effects on long-term follow-up outcomes in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction
Şükrü Arslan, Servet Batıt, Onur Kılıçarslan, Ömer Doğan, Mehmet Tugay Yumuk, Şeyma Arslan, İsmail Haberal, Cüneyt Koçaş, Sait Mesut Doğan, Okay Abacı
doi: 10.5152/AnatolJCardiol.2021.26020  Pages 609 - 616

4.Determinants of gait speed in patients with heart failure with reduced ejection fraction
Aylin Tanrıverdi, Buse Özcan Kahraman, Serap Acar, İsmail Özsoy, Ebru Özpelit, Bihter Şentürk, Bahri Akdeniz, Sema Savcı
doi: 10.5152/AnatolJCardiol.2021.17735  Pages 617 - 622

5.Post percutaneous coronary intervention hemoglobin levels predict in-hospital mortality in patients with STEMI treated with primary percutaneous coronary intervention
Gönül Zeren, İlhan İlker Avcı, Barış Şimşek, Azmi Sungur, Tufan Çınar, Veysel Ozan Tanık, Duygu Genç, Göksel Çinier, Can Yücel Karabay
doi: 10.5152/AnatolJCardiol.2021.07282  Pages 623 - 629

6.MiRNA-130a promotes inflammation to accelerate atherosclerosis via the regulation of proliferator-activated receptor γ (PPARγ) expression
Fengtong Liu, Yali Liu, Yuqing Du, Youshan Li
doi: 10.5152/AnatolJCardiol.2021.56721  Pages 630 - 637

7.Impact of kidney function on the occurrence of new-onset atrial fibrillation in patients with ST-elevation myocardial infarction
Lidija Savic, Igor Mrdovic, Milika Asanin, Sanja Stankovic, Gordana Krljanac, Ratko Lasica, Mihajlo Viduljevic
doi: 10.5152/AnatolJCardiol.2021.35332  Pages 638 - 645

8.A new score model to predict the inducibility of supraventricular tachycardia in patients with palpitation without documented electrocardiography
Yusuf Türkmen, Naci Babat
doi: 10.5152/AnatolJCardiol.2021.51152  Pages 646 - 652

9.Gamma-glutamyl transferase to albumin ratio can predict severity of coronary artery disease detected by coronary computed tomography angiography
Salih Topal, Emrullah Kızıltunç, Burak Sezenöz, Mustafa Candemir, Serkan Ünlü, Muhammet Küçükbardaslı, Ayşe Nihan Bal, Hüseyin Koray Kılıç, Gonca Erbaş, Adnan Abacı
doi: 10.5152/AnatolJCardiol.2021.36330  Pages 653 - 660

10.Apixaban for massive intracoronary thrombosis: A case series
Kerim Esenboğa, Ebru Şahin, Nil Özyüncü, Türkan Seda Tan, Yusuf Atmaca
doi: 10.5152/AnatolJCardiol.2021.32746  Pages 661 - 664
Abstract | Full Text PDF

11.Sustained response to targeted therapies in a patient with pulmonary hypertension owing to Langerhans cell histiocytosis
Aykun Hakgör, Hacer Ceren Tokgöz, Özgür Yaşar Akbal, Seda Tanyeri, Berhan Keskin, Barkın Kültürsay, Ali Karagöz, Cihangir Kaymaz
doi: 10.5152/AnatolJCardiol.2021.49500  Pages 665 - 668
Abstract | Full Text PDF

12.Successful management of a foreseeable and preventable complication of transcatheter valve implantation
Ali Rıza Akyüz, Levent Korkmaz
doi: 10.5152/AnatolJCardiol.2021.37383  Pages 669 - 670
Abstract | Full Text PDF

13.Successful percutaneous transvenous removal of a fractured port catheter via novel technique: Balloon-supported retrieval
Mustafa Doğduş, Ferhat Dindaş, Erdem Türkyılmaz, Barış Dindar, Barış Tunçer, Özkan Candan
doi: 10.5152/AnatolJCardiol.2021.62186  Pages 671 - 672
Abstract | Full Text PDF

14.Higher risk of long QT syndrome and atrial flutter in adults with HIV admitted for acute myocardial infarction
Kamleshun Ramphul, Nomesh Kumar, Renuka Verma, Yogeshwaree Ramphul, Petras Lohana, Stephanie G. Mejias, Jyotsnav Joynauth
doi: 10.5152/AnatolJCardiol.2021.222  Pages 673 - 674
Abstract | Full Text PDF

15.Genetic counseling of ventricular tachycardias
Hande Kaymakçalan Çelebiler
doi: 10.5152/AnatolJCardiol.2021.412  Pages 675 - 676
Abstract | Full Text PDF

16.Rumpel-Leede phenomenon after right radial catheterization procedure
Jahanzeb Malik
doi: 10.5152/AnatolJCardiol.2021.117  Page E33
Abstract | Full Text PDF

17.Invasive myocardial calcification of left ventricle associated with conduction disturbances, hypophosphatemia, and childhood rickets
Kerem M. Vural, Burak Ateşsaçan, Can Kerestecioğlu, Furkan Gül
doi: 10.5152/AnatolJCardiol.2021.00748  Pages E34 - E35
Abstract | Full Text PDF

18.Spontaneous, severe, and diffuse coronary vasospasm in a patient with COVID-19
Mutlu Çağan Sümerkan, Arzu Er Kara, Güneş Melike Doğan, Ömer Alyan
doi: 10.5152/AnatolJCardiol.2021.167  Pages E36 - E37
Abstract | Full Text PDF

Zhixian Tang, Mengya Liang, Guangxian Chen, Jian Rong, Jianping Yao, Zhen Chen, Xiao Yang, Zhongkai Wu. Neuroprotective effect of selective antegrade cerebral perfusion during prolonged deep hypothermic circulatory arrest: Cerebral metabolism evidence in a pig model. Anatol J Cardiol. 2018; 19(1): 2-10

Corresponding Author: Zhongkai Wu, China