ISSN 2149-2263 | E-ISSN 2149-2271
The Anatolian Journal of Cardiology
Malnutrition Predicts Adverse Outcomes After Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis [Anatol J Cardiol]
Anatol J Cardiol. 2023; 27(5): 240-248 | DOI: 10.14744/AnatolJCardiol.2023.2710

Malnutrition Predicts Adverse Outcomes After Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis

Mingqi Dong1, Jifang Cheng2, Li Gong3, Yajing Xiao4, Shengwen Shao5, Jianping Song1
1Department of Nursing, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou City, China
2Cardiac Intervention Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou City, China
3Department of Cardiology, Yuechi County People’s Hospital, Sichuan Province, China
4School of Nursing, School of Medicine, Huzhou University, Huzhou City, China
5School of Medicine, Huzhou University, Huzhou City, China

Background: Several studies have shown that malnutrition helps to predict the occurrence of adverse outcomes after transcatheter aortic valve replacement. However, there is still controversy and uncertainty regarding the prevalence and consequences of malnutrition. We performed a systematic review and meta-analysis to assess the relationship between malnutrition and poor postoperative outcomes in transcatheter aortic valve replacement.

Methods: Observational studies were searched in PubMed, EMBASE, Cochrane Library, Web of Science, and MEDLINE regarding the relationship between malnutrition and adverse outcomes after transcatheter aortic valve replacement, with the primary end-point being all-cause mortality and secondary outcomes such as cardiovascular complications and readmission rates. This meta-analysis was registered in PROSPERO (number CRD42022310139).

Results: A total of 10 studies involving 5936 subjects were included in the systematic review and meta-analysis. The results showed that malnourished patients had an increased risk of all-cause mortality after transcatheter aortic valve replacement compared with non-malnourished patients (hazard ratios [HR] = 1.32, 95% CI [1.13, 1.53], P <.01). Subgroup analysis showed that in Asia, postoperative all-cause mortality was significantly higher in malnourished transcatheter aortic valve replacement patients than in non-malnourished transcatheter aortic valve replacement patients (P <.01), and in addition, sample size and follow-up time may have contributed to the large heterogeneity.

Conclusion: Malnutrition increases the risk of all-cause mortality in such patients and may predict the occurrence of adverse postoperative outcomes.

Keywords: Malnutrition, transcatheter aortic valve replacement, mortality

Mingqi Dong, Jifang Cheng, Li Gong, Yajing Xiao, Shengwen Shao, Jianping Song. Malnutrition Predicts Adverse Outcomes After Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis. Anatol J Cardiol. 2023; 27(5): 240-248

Corresponding Author: Jianping Song
Manuscript Language: English


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