ISSN 2149-2263 | E-ISSN 2149-2271
The Anatolian Journal of Cardiology
A relationship between CRP, adiponectin and Gensini score in the patients with coronary artery disease [Anatol J Cardiol]
Anatol J Cardiol. 2011; 11(3): 195-200 | DOI: 10.5152/akd.2011.052

A relationship between CRP, adiponectin and Gensini score in the patients with coronary artery disease

Dursun oğlu1, Hidayet Göksoy2, Mehmet Öztürk2, Simin Rota4
1Pamukkale Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Denizli, Türkiye
2Pamukkale Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Denizli, Türkiye
3Pamukkale Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Denizli, Türkiye
4Pamukkale Üniversitesi Tıp Fakültesi, Biyokimya Anabilim Dalı, Denizli, Türkiye

Objective: We aimed to evaluate serum adiponectin and C-reactive protein (CRP) levels in the different groups of patients with angiographically defined coronary artery disease (CAD). Methods: Overall 100 patients (80 males, 20 females) with CAD (≥ 50% stenosis) and 45 controls (25 males, 20 females) with normal coronary arteries were included in this cross-sectional observational study. Gensini score was used for evaluation of the severity of coronary lesions on the angiogram. A relationship between Gensini score and serum CRP and adiponectin levels was evaluated by a logistic regression analysis. Results: Mean age of the patients (60.5±10.2 years) was significantly higher than of the controls (55.6±10.4 years, p=0.01). While serum adiponectin levels in CAD patients (2.1±1.2 µmg/dl) were significantly lower than in the controls (3.3±1.8 µmg/dl, p=0.01); serum CRP levels of the patients (2.8±1.5 mg/dl) were significantly higher than of the controls (0.9±0.4 mg/dl). Serum adiponectin and CRP levels were not significantly different between the CAD subgroups (p>0.05). Gensini score was related with serum CRP (odds ratio: 0.98, 95% CI: 1.05-1.35, p=0.01) and adiponectin levels (odds ratio: 1.15, 95% CI: 1.10-1.25, p=0.01) by a logistic regression analysis. Conclusion: While serum CRP levels are increased in CAD patients comparing with the controls; serum adiponectin levels are decreased significantly. Serum CRP and adiponectin levels are related to coronary lesions severity on the angiogram.

Keywords: Coronary artery disease, C-reactive protein, adiponectin, angiography, Gensini score, logistic regression analysis

Dursun oğlu, Hidayet Göksoy, Mehmet Öztürk, Simin Rota. A relationship between CRP, adiponectin and Gensini score in the patients with coronary artery disease. Anatol J Cardiol. 2011; 11(3): 195-200
Manuscript Language: English


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