ISSN 2149-2263 | E-ISSN 2149-2271
The Anatolian Journal of Cardiology
Prognostic Factors of Mitral Stenosis During Pregnancy [Anatol J Cardiol]
Anatol J Cardiol. 2002; 2(3): 213-217

Prognostic Factors of Mitral Stenosis During Pregnancy

İbrahim Demir1, Hüseyin Yılmaz1, İbrahim Başarıcı1, R. Emre Altekin1, Gürkan Zorlu2
1Akdeniz Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı, Antalya, Türkiye
2Akdeniz Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı, Antalya

Objective: To identify characteristics associated with complications during pregnancy in patients with mitral stenosis. Methods: Thirty-seven pregnant women with mitral stenosis, followed-up from 1998 to 2001 were evaluated. Predictor variables were the mitral valve area (MVA) measured by echocardiogram and functional class (FC) before pregnancy according to NYHA criteria. Progression of functional class, thromboembolism, death, need in medical abortion, cardiac surgery or balloon mitral valvulotomy were accepted as maternal events. Fetal/neonatal events were determined as abortion, fetal or neonatal death, prematurity or low birth weight (<2.500g), and extended stay in the nursery or hospitalization in newborn intensive care unit. Results: The mean ± SD of age of the patients was 24.7±5.8 years. The eventful and uneventful patients were similar in age and percentage of first pregnancies. Of patients with an events occuring during gestational period, 37. 5% had class I functional capacity whereas 62.5% had class II/III (p=0.001). A clinical event was noted in 34 % of the patients with sinus rhythm and in all of patients with atrial fibrillation (p=0.007). The mean mitral valve area was 1.11±0.23 cm2 in the group with clinical event and 1.6±0.27 cm2 in the group without an event (p<0.001). The most frequently observed maternal complication was the worsening of the functional capacity and the most frequent fetal/neonatal complications were prematurity and low birth weight. Mitral valve area and functional capacity were found to be significantly related with maternal complications but not with the fetal/neonatal complications. Conclusion: In pregnant women with mitral stenosis, the MVA and the FC are strongly associated with maternal complications but not related to fetal/neonatal events.


İbrahim Demir, Hüseyin Yılmaz, İbrahim Başarıcı, R. Emre Altekin, Gürkan Zorlu. Prognostic Factors of Mitral Stenosis During Pregnancy. Anatol J Cardiol. 2002; 2(3): 213-217
Manuscript Language: English


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