ISSN 2149-2263 | E-ISSN 2149-2271
Volume : Issue : Year : 2021
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The Anatolian Journal of Cardiology Surgical treatment for improved 1-year survival in patients with primary cardiac sarcoma [Anatol J Cardiol]
Anatol J Cardiol. Ahead of Print: AJC-60378

Surgical treatment for improved 1-year survival in patients with primary cardiac sarcoma

Xiaowei Jiang1, Min Yan2
1Cardiology department, Xiangya hospital Central South University, Changsha, Hunan, China
2Internal medicine department, Changsha Medical University, Changsha, Hunan, China

Objective: Surgery is considered as a relative contraindication in sarcoma tumor. Due to the special of heart, whether surgery is an optimally chooses in primary cardiac sarcoma (PCS) is unknown. This study aimed to evaluate the 1-year survival of surgery for PCS.
Methods: PCS patients from the Surveillance, Epidemiology, and End Results Database (SEER) between 1975 and 2015 were recruited. The endpoint was defined as 1-year all-causes mortality(ACM) and 1-year cancer-specific mortality(CSM).
Results: The study population consisted of 335 patients diagnosed with PCS. The 1-year ACM & CSM were 49.0% and 42.1% respectively. The Kaplan-Meier curves revealed that decreased 1-year ACM & CSM were significantly associated with treatment of surgery. Multivariate COX regression analysis, surgery and chemotherapy showed significant decreased rate of 1-year ACM & CSM. The adjust HR of surgery were significant in the year of diagnosis(>=2000), age(<50), SEER stage (localized), and chemotherapy (No) (all p <0.05), and insignificantly in year of diagnosis(<2000), age(>=50), SEER stage (distance, regional, and unstage/unknown) and chemotherapy(Yes) (all p >0.05). None interactive effects between variables and surgery were detected (all p for interaction >0.05).
Conclusion: Surgery should be highly recommended in patients with primary cardiac sarcoma to improve 1-year survival rate, especially in younger, localized of SEER stage, and non-chemotherapy management.
KEY WORDS: primary cardiac sarcoma; surgery; subgroup analysis

Keywords: primary cardiac sarcoma, surgery, subgroup analysis



Corresponding Author: Min Yan, China