ISSN 2149-2263 | E-ISSN 2149-2271
The Anatolian Journal of Cardiology
Duration of Ciprofloxacin Use Is Important in the Development of Abdominal Aortic Aneurysm in a Rat Model [Anatol J Cardiol]
Anatol J Cardiol. 2022; 26(11): 810-817 | DOI: 10.5152/AnatolJCardiol.2022.1939

Duration of Ciprofloxacin Use Is Important in the Development of Abdominal Aortic Aneurysm in a Rat Model

Yekta Çulpan1, İrem Keçeci2, İrem Sandıkçı2, Şeyda Gökçe2, Hande Göker2, Nagehan Özyılmaz Yay3, Rabia Ergelen4, Dilek Akakın3, Rezzan Gülhan Aker1
1Department of Medical Pharmacology, Faculty of Medicine, Marmara University, İstanbul, Turkey
2Faculty of Medicine, Marmara University, İstanbul, Turkey
3Department of Histology and Embryology, Faculty of Medicine, Marmara University, İstanbul, Turkey
4Department of Radiology, Faculty of Medicine, Marmara University, İstanbul, Turkey

Background: Recent findings suggest that fluoroquinolones, most prescribed antibiotic to treat various infections, have increased abdominal aortic aneurysm formation. We aimed to investigate the relation of the development of abdominal aortic aneurysm and the duration of ciprofloxacin use.

Methods: Male Sprague–Dawley rats were divided into 2 groups to administer saline to the control groups and CaCl2 to the aneurysm groups. These groups were then divided into 3 subgroups: intraperitoneal saline, ciprofloxacin for 2 weeks, and ciprofloxacin for 4 weeks. At the end of 4 weeks, the diameter of abdominal aorta was determined by ultrasonography and animals were sacrificed to obtain abdominal aorta specimens. Elastic fiber fracture, tunica media layer thickness, and aortic tissue damage were evaluated histologically.

Results: Aortic diameter of control-saline (2.15 mm ± 0.06), control-2 weeks (2.25 mm ± 0.06), and control-4 weeks (3.31 mm ± 0.09) ciprofloxacin groups was significantly different (P <.0001). Also, aortic diameter of aneurysm-saline (2.07mm ± 0.02), aneurysm-2 weeks ciprofloxacin (3.33 mm ± 0.64), and aneurysm-4 weeks ciprofloxacin (8.55 mm ± 1.70) groups showed significant increase in aortic diameter with increasing duration of ciprofloxacin use (P <.01). A significant difference was found between the control-saline (0.00 ± 0.00), control-2 weeks (1.50 ± 0.33), and control-4 weeks ciprofloxacin groups (1.57 ± 0.20) in the histological aneurysm scores (P <.001). Aortic tunica media thickness did not change between control-saline and control-ciprofloxaci n groups (P >.05).

Conclusion: The study showed that ciprofloxacin caused injury in the aortic wall but not a significant change in the thickness of the aortic tunica media layer. The duration of ciprofloxacin use was important in the development of aneurysm and aneurysm severity.

Keywords: Ciprofloxacin, aneurysm, aorta

Yekta Çulpan, İrem Keçeci, İrem Sandıkçı, Şeyda Gökçe, Hande Göker, Nagehan Özyılmaz Yay, Rabia Ergelen, Dilek Akakın, Rezzan Gülhan Aker. Duration of Ciprofloxacin Use Is Important in the Development of Abdominal Aortic Aneurysm in a Rat Model. Anatol J Cardiol. 2022; 26(11): 810-817

Corresponding Author: Yekta Çulpan
Manuscript Language: English


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Journal Citation Indicator: 0.18
CiteScore: 1.1
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