ISSN 2149-2263 | E-ISSN 2149-2271
The Anatolian Journal of Cardiology
Is slow coronary flow related with inflammation and procoagulant state [Anatol J Cardiol]
Anatol J Cardiol. 2005; 5(1): 3-7

Is slow coronary flow related with inflammation and procoagulant state

Mustafa Yazıcı1, Emre Aksakal1, Sabri Demircan2, Mahmut Şahin1, Olcay Sağkan1
1Ondokuz Mayıs Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı, Samsun, Türkiye
2Department of Cardiology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey

Objective: To investigate the pathogenesis of coronary slow flow (CSF), C-reactive protein (CRP) levels as indicator of inflammation and procoagulant activity were studied in patients with CSF. Methods: Fifty-one patients (22 female, mean age; 53±10 years) who were admitted to our clinic with chest pain and had the diagnosis of CSF established by TIMI frame count method and coronary angiography, and 44 healthy subjects (18 female, mean age; 54±6 years) with normal coronary flow (NCF) were included in the study. Subjects with any infectious and systemic immune disease were excluded from the study. The CRP levels were measured from venous blood samples during admission, at 24th hour and after 3 months in all subjects. Additionally; fibrinogen, plasminogen, plasminogen activator inhibitor (PAI-1), tissue plasminogen activator (t-PA) and von Willebrand factor (vWF) levels were measured to determine the procoagulant activity. Results: There was no significant difference between CRP levels of patients with CSF and healthy subjects during admission (7.26±4.2 ng/dl vs. 6.43±2.8 ng/dl, p>0.05), at 24th hour (7.84±1.3 ng/dl vs. 6.32±2.5 ng/dl, p>0.05) and after 3 months (6.37±2.4 ng/dl vs. 6.18±3.3 ng/dl, p>0.05). There were no differences between levels of CRP when compared according to the TIMI frame count, number of vessels with CSF and artery in which CSF was dominant. Additionally; procoagulant activity assessed by fibrinogen, plasminogen, PAI-1, t-PA and vWF levels was similar in both groups. Conclusion: Our findings on normal levels of CRP and procoagulant activity, and lack of relation with TIMI frame count made us to think that inflammatory and procoagulant activity did not play a role in the pathogenesis of CSF.

Keywords: Coronary slow flow, inflammation, C-reactive protein, procoagulant activity

Mustafa Yazıcı, Emre Aksakal, Sabri Demircan, Mahmut Şahin, Olcay Sağkan. Is slow coronary flow related with inflammation and procoagulant state. Anatol J Cardiol. 2005; 5(1): 3-7
Manuscript Language: English

Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
SCImago Journal Rank: 0.348

Quick Search

Copyright © 2024 The Anatolian Journal of Cardiology

Kare Publishing is a subsidiary of Kare Media.