Review
G-CSF in acute myocardial infarction - Experimental and clinical findings
1From the Department of Medicine, Divisions of Cardiology at the University Hospital Rostock, Rostock School of Medicine, Rostock, Germany
2From the Department of Nuclear Medicine at the University Hospital Rostock, Rostock School of Medicine, Rostock, Germany
2From the Department of Nuclear Medicine at the University Hospital Rostock, Rostock School of Medicine, Rostock, Germany
Anatol J Cardiol 2006; 3(6): 261-263 PubMed ID: 16943113
Abstract
Early data from clinical studies suggest that intracoronary injection of autologous progenitor cells may beneficially affect postinfarction remodeling and perfusion. Beyond intracoronary infusion of autologous bone marrow mononuclear CD34+ cells (MNCCD34+), mobiliza- tion of stem cells by G-CSF has recently attracted attention because of various advantages such as the noninvasive nature of MNCCD34+ mobilization by subcutaneous injections. It is the aim of the present work to give an overview about the current experimental and clinical findings of G-CSF treatment in acute myocardial infarction.
Keywords: G-CSF, myocardial infarction, stem cells