ISSN 2149-2263 | E-ISSN 2149-2271
The Anatolian Journal of Cardiology
Inhibitory effects of ticlopidine and clopidogrel on the intimal hyperplastic response after arterial injury [Anatol J Cardiol]
Anatol J Cardiol. 2010; 10(1): 11-16

Inhibitory effects of ticlopidine and clopidogrel on the intimal hyperplastic response after arterial injury

Tuğrul Göncü1, Osman Tiryakioğlu1, Ayhan Özcan3, Hasan Arı4, Mustafa Sezen5, Hakan Vural6, Ahmet Bayer7, Serhat Yalçınkaya8, Şenol Yavuz9, Ahmet Özyazıcıoğlu6
1Department of Cardiovascular Surgery, Bursa Yüksek İhtisas Education and Research Hospital, Bursa, Turkey
2Department of Cardiovascular Surgery, Bursa Yüksek İhtisas Education and Research Hospital, Bursa, Turkey
3Department of Cardiovascular Surgery Bursa Yüksek İhtisas Education and Research Hospital, Bursa, Turkey
41st Clinic of Cardiology, Bursa Subspecialization Training and Research Hospital, Bursa, Turkey
5Department of Cardiovascular Surgery Bursa Yüksek İhtisas Education and Research Hospital, Bursa, Turkey
6Clinic of Cardiovascular Surgery, Bursa Yüksek İhtisas Training and Research Hospital
7Department of Pathology Bursa Yüksek İhtisas Education and Research Hospital, Bursa, Turkey
8Department of Thoracic Surgery, Bursa Yüksek İhtisas Education and Research Hospital, Bursa, Turkey
9Clinic of Cardiovascular Surgery, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey

Objective: The purpose of this study was to compare the effects of ticlopidine and clopidogrel on the development of neointimal hyperplasia after experimental arterial injury. Methods: This experimental, prospective, randomized controlled study was performed on twenty-seven rabbits, which were divided into three groups, each of which contained nine subjects. Following the development of a balloon catheter injury in the iliac artery, no drugs were administered to Group 1 (control). Group 2 was given ticlopidine, while Group 3 was given clopidogrel. At the end of the 21-day experimental period, arterial sections were evaluated histomorphologically and immunohistochemically with staining using antibodies against platelet derived growth factor β and basic fibroblast growth factor. Statistical analyses were performed using Chi-Square, Mann Whitney U and one-way ANOVA tests. Results: At the end of study period, ticlopidine and clopidogrel strongly reduced the development of intimal hyperplasia after arterial injury (54.1%, p<0.001, 53.2%, p<0.001, respectively). No significant difference was observed in terms of intimal and medial areas between the drug-treated groups. Expressions of the basic fibroblast growth factor and platelet derived growth factor β were significantly lower in the intima of drug treated groups with respect to the control group (p<0.05). Conclusion: The results of our study suggest that ticlopidine and clopidogrel, which are widely used in antiplatelet treatment in clinics, can similarly prevent the development of intimal hyperplasia after experimental arterial injury.

Keywords: Ticlopidine, clopidogrel, intimal hyperplasia, restenosis, iliac artery

Tuğrul Göncü, Osman Tiryakioğlu, Ayhan Özcan, Hasan Arı, Mustafa Sezen, Hakan Vural, Ahmet Bayer, Serhat Yalçınkaya, Şenol Yavuz, Ahmet Özyazıcıoğlu. Inhibitory effects of ticlopidine and clopidogrel on the intimal hyperplastic response after arterial injury. Anatol J Cardiol. 2010; 10(1): 11-16
Manuscript Language: English


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