2Department of Cardiology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey
3Clinic of Cardiology, Aydın Medline Hospital, Aydın-Turkey
Abstract
Objective: In this study, we aimed to investigate effects of metoprolol treatment on transmitral, pulmonary venous flows and spontaneous echo contrast in patients with heart failure. Materials and Methods: Twenty-four patients (mean age: 55±8 years) with heart failure were enrolled to the study. All were given metoprolol succinate with titrated target dose of 50 mg/d controlled release tablets for 1 month. Transmitral flow and pulmonary venous flow, systolic, diastolic and atrial reversal flow velocities were measured, and compared with the pretreatment values. Results: Heart rate significantly decreased. No significant change was observed in ejection fraction. When the post treatment values were compared with the pretreatment values, it was detected that isovolumetric relaxation time significantly decreased (p<0.05), mitral E wave and E/A ratio were significantly increased (p<0.05 and p<0.05, respectively) after the treatment. A significant increase was observed in pulmonary vein systolic velocity after metoprolol treatment (p<0.05). Conclusion: Metoprolol treatment can cause an improvement in transmitral and pulmonary venous flows.