ISSN 2149-2263 | E-ISSN 2149-2271
Volume : 20 Issue : 4 Year : 2021
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The Anatolian Journal of Cardiology Time-dependent cervical vagus nerve stimulation and frequency-dependent right atrial pacing mediates induction of atrial fibrillation [Anatol J Cardiol]
Anatol J Cardiol. 2018; 20(4): 206-212 | DOI: 10.14744/AnatolJCardiol.2018.73558

Time-dependent cervical vagus nerve stimulation and frequency-dependent right atrial pacing mediates induction of atrial fibrillation

Mingliang Rao1, Jialu Hu2, Yan Zhang3, Feng Gao4, Feng Zhang5, Zhi Yang5, Xiaoya Zhang1, Yuemei Hou1
1Department of Cardiology, Affiliated Fengxian Hospital, Southern Medical University (Shanghai Fengxian Central Hospital); Shanghai-China
2Department of Cardiology, Zhongshan Hospital Affiliated to Fudan University; Shanghai-China
3Department of Cardiology, First Hospital of Fuzhou City; Fujian-China
4Department of Cardiology, Zhongshan Hospital Affiliated to Xiamen University; Fujian-China
5Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University; Xinjiang-China

Objective: This study aimed to investigate the effects of right cervical vagus trunk simulation (RVTS) and/or right atrial pacing (RAP) on the induction of atrial fibrillation (AF).
Methods: Twenty-four healthy adult dogs were randomly divided into four groups: RAP groups comprising RAP500 (RAP with 500 beats/min) and RAP1000 (RAP with 1000 beats/min) and RVTS groups comprising RVTS and RAP500+RVTS. All dogs underwent 12-h intermittent RAP and/or RVTS once every 2 h. The AF induction rate, AF duration, atrial effective refractory period (ERP), and dispersion of ERP (dERP) were compared after every 2 h of RAP or/and RVTS.
Results: All groups had successful AF induction. The RAP1000 group had the highest AF induction rate and the longest AF duration. The RAP1000 group also had a shortened ERP in comparison to the other groups as well as the maximum dERP. Compared to the RAP500 group, RAP500+RVTS had an increased capacity to induce AF as measured by the AF induction rates, AF duration, ERP, and dERP.
Conclusion: Increased tension in the vagus nerve and the intrinsic cardiac autonomic nervous system plays an important role in AF induction through different potential mechanisms. Interventions involving the vagus nerve and/or intrinsic cardiac autonomic nervous system can be a future potential therapy for AF.

Keywords: vagus trunk, right atrial pacing, atrial fibrillation, intrinsic cardiac autonomic nervous system

Mingliang Rao, Jialu Hu, Yan Zhang, Feng Gao, Feng Zhang, Zhi Yang, Xiaoya Zhang, Yuemei Hou. Time-dependent cervical vagus nerve stimulation and frequency-dependent right atrial pacing mediates induction of atrial fibrillation. Anatol J Cardiol. 2018; 20(4): 206-212

Corresponding Author: Yuemei Hou, China
Manuscript Language: English