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Volume : 11 Issue : 6 Year : 2021
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The Anatolian Journal of Cardiology Clinical significance of intestinal type fatty acid binding protein in patients undergoing coronary artery bypass surgery [Anatol J Cardiol]
Anatol J Cardiol. 2011; 11(6): 536-541 | DOI: 10.5152/akd.2011.139

Clinical significance of intestinal type fatty acid binding protein in patients undergoing coronary artery bypass surgery

Aynur Camkıran1, Aslı Dönmez2, Derya Aldemir3, Rauf Agah İşgüzar1, Bahadır Gültekin3
1Department of Anesthesiology, Faculty of Medicine, Başkent University, Ankara-Turkey
2Clinic of Anesthesiology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara-Turkey
3Department of Cardiovascular Surgery, Faculty of Medicine, Başkent University, Ankara-Turkey

Objective: The aim of this study was to determine whether serum levels of intestinal type fatty acid binding protein (I-FABP) are related to intestinal ischemia in patients undergoing coronary bypass surgery. Methods: The study was planned as prospective, observational. Elective coronary artery bypass candidate patients between ages of 50 and 70 were consecutively included in the study. Thirty-five patients scheduled for cardiopulmonary bypass (CPB) were identified as the CPB group and 16 patients not scheduled for CPB were identified as the off-pump coronary artery bypass surgery (OPCAB) group. The variables between and within the groups were analyzed with Student’s t, Mann-Whitney U, Friedman and Wilcoxon tests respectively. Results: In both CPB and OPCAB groups, I-FABP level at the end of the operation was significantly higher than that noted at the beginning of the operation (p<0.005). In the CPB group, there was a significant drop in I-FABP from the end of the operation to each of the postoperative time points (12th hour and 24th hour) (respectively p<0.001, p<0.001). In the OPCAB group, the I-FABP levels at both postoperative time points were lower than that at the end of the operation (p<0.001), and the level at 24-hour post-surgery was significantly lower than at both the end-of-operation I-FABP value (p<0.001) and the 12-hour post-surgery I-FABP value. Conclusion: Since we have not observed any intestinal ischemia through our research, slight changes of I-FABP measurements make us believe that I-FABP would be a valuable way to monitor for intestinal ischemia in patients who undergo cardiac surgery.

Keywords: Coronary artery bypass grafting surgery, intestinal ischemia, intestinal fatty acid binding protein

Aynur Camkıran, Aslı Dönmez, Derya Aldemir, Rauf Agah İşgüzar, Bahadır Gültekin. Clinical significance of intestinal type fatty acid binding protein in patients undergoing coronary artery bypass surgery. Anatol J Cardiol. 2011; 11(6): 536-541