ISSN 2149-2263 | E-ISSN 2149-2271
The Anatolian Journal of Cardiology
Association between serum adropin levels and isolated coronary artery ectasia in patients with stable angina pectoris [Anatol J Cardiol]
Anatol J Cardiol. 2019; 22(5): 250-255 | DOI: 10.14744/AnatolJCardiol.2019.90349

Association between serum adropin levels and isolated coronary artery ectasia in patients with stable angina pectoris

Buğra Özkan1, Özcan Örsçelik1, Hatice Yıldırım Yaroğlu2, Şenay Balcı2, Mert Koray Özcan1, Ahmet Çelik1, Ismail Türkay Özcan1
1Department of Cardiology, Faculty of Medicine, Mersin University; Mersin-Turkey
2Department of Biochemistry, Faculty of Medicine, Mersin University; Mersin-Turkey

Objective: Dilation of one or more coronary artery segments to a diameter at least 1.5 times that of a normal adjacent segment is referred to as coronary artery ectasia (CAE). Adropin is a protein involved in endothelial function and is shown to have a protective effect on the regulation of cardiac functions. Atherosclerosis and endothelial dysfunction play an important role in the development of CAE. The aim of this study was to investigate the association between serum adropin levels and isolated CAE.
Methods: Patients with stable angina pectoris who underwent coronary angiography (CAG) between August 2017 and July 2018 were evaluated prospectively. A total of 92 subjects were included in the study-40 patients over 18 years old and diagnosed with isolated CAE based on CAG findings and a control group of 52 patients.
Results: Serum adropin level was found to be significantly lower in the isolated CAE group compared to the control group (1019.57 pg/mL and 1151.10 pg/mL, respectively, p=0.010). The isolated CAE group also exhibited a significantly higher mean platelet volume than that in the control group (10.75 fL and 10.17 fL, respectively, p=0.011).
Conclusion: Our results show that there is an association between low serum adropin level and isolated CAE.

Keywords: endothelial dysfunction, coronary artery ectasia, adropin

Buğra Özkan, Özcan Örsçelik, Hatice Yıldırım Yaroğlu, Şenay Balcı, Mert Koray Özcan, Ahmet Çelik, Ismail Türkay Özcan. Association between serum adropin levels and isolated coronary artery ectasia in patients with stable angina pectoris. Anatol J Cardiol. 2019; 22(5): 250-255

Corresponding Author: Buğra Özkan, Türkiye
Manuscript Language: English


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