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The Anatolian Journal of Cardiology The relation between aortic atherosclerosis and risk factors [Anatol J Cardiol]
Anatol J Cardiol. 2007; 7(1): 2-5

The relation between aortic atherosclerosis and risk factors

Abdi Bozkurt1, Murat Çaylı2, Mesut Demir3, Cumhur Alhan4, Esmeray Acartürk1
1Department of Cardiology, School of Medicine, Çukurova University, 01330, Adana, Turkey
2Çukurova Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Adana, Türkiye
3Çukurova Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı, Adana, Türkiye
4Department of Cardiology, School of Medicine, Çukurova University, Adana, Turkey
5Department of Cardiology, School of Medicine, Çukurova University, 01330, Adana, Turkey

Objective: To evaluate the impact of risk factors on atherosclerotic changes of aortic wall and valve in patients with and without non-familial hypercholesterolemia by transthoracic echocardiography. Methods: One hundred and eleven patients with non-familial hypercholesterolemia and 112 control subjects were included in the study. Aortic wall and valve were evaluated by visual assessment of wall hyperechogenicity and measuring the valve thickness. Aortic diameters were obtained at the levels of annulus, sinus of Valsalva and at the supravalvular level in the parasternal long-axis view by M-Mode echocardiographic examination. The relationship between parameters of aortic atherosclerosis and risk factors was studied by multivariate logistic regression analysis, Pearson and Spearman correlation analyses. Results: The prevalence of aortic wall hyperechogenicity was found to be higher in patients with hypercholesterolemia (84.7% vs 70.5%, p=0.01). The mean aortic root diameters at all levels of patients with hypercholesterolemia were found to be significantly smaller than in patients of the control group (3.1±0.3 mm vs 3.2±0.5 mm, p=0.02 for annulus level, 3.4±0.4 mm vs 3.5±0.4, p=0.004 mm for the level of sinus of Valsalva and 3.2±0.3 mm vs 3.4±0.5 mm, p<0.001 – supravalvular level), but no difference was noted regarding the aortic velocity and pressure gradient across the aortic valve. Multivariate stepwise logistic regression analysis showed that age (OR=1.1, CI – 1.02-1.09, p=0.002) and smoking (OR=2.2, CI – 1.06-4.58, p=0.04) were independent predictors of aortic valve thickness. Hypercholesterolemia was an independent predictor for aortic wall hyperechogenicity (OR=2.5, CI – 1.3-4.9, p=0.009) but not for valve thickness. Conclusions: Age, smoking and hypercholesterolemia are related to atherosclerotic involvement of aortic wall and valve.

Keywords: Aortic atherosclerosis, risk factors, transthoracic echocardiography, regression analysis

Aort aterosklerozu ile risk faktörleri arasındaki ilişki

Abdi Bozkurt1, Murat Çaylı2, Mesut Demir3, Cumhur Alhan4, Esmeray Acartürk1
1Department of Cardiology, School of Medicine, Çukurova University, 01330, Adana, Turkey
2Çukurova Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Adana, Türkiye
3Çukurova Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı, Adana, Türkiye
4Department of Cardiology, School of Medicine, Çukurova University, Adana, Turkey
5Department of Cardiology, School of Medicine, Çukurova University, 01330, Adana, Turkey

Anahtar Kelimeler: Aort aterosklerozu, risk faktörleri, transtorasik ekokardiyografi, regresyon analiz

Abdi Bozkurt, Murat Çaylı, Mesut Demir, Cumhur Alhan, Esmeray Acartürk. The relation between aortic atherosclerosis and risk factors. Anatol J Cardiol. 2007; 7(1): 2-5
Manuscript Language: English