ISSN 2149-2263 | E-ISSN 2149-2271
The Anatolian Journal of Cardiology
Molecular Approach of Hereditary Arrhythmias, Long QT Syndrome, and Arrhythmogenic Right Ventricular Cardiomyopathy [Anatol J Cardiol]
Anatol J Cardiol. 2022; 26(6): 460-465 | DOI: 10.5152/AnatolJCardiol.2022.1324

Molecular Approach of Hereditary Arrhythmias, Long QT Syndrome, and Arrhythmogenic Right Ventricular Cardiomyopathy

Hanife Saat1, Ibrahim Şahin1, Haktan Bagğış Erdem2, Senem Özgür3, Semiha Terlemez Tokgöz4, Taha Bahsi&775;2
1Department of Medical Genetics, University of Health Sciences, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Ankara, Turkey
2Department of Medical Genetics, University of Health Sciences, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey
3Department of Pediatric Cardiology, Dr. Sami Ulus Maternity, Children's Health and Diseases Training and Research Hospital, Ankara, Turkey
4Department of Pediatric Cardiology, Faculty of Medicine, Gazi University, Ankara, Turkey

Background: Hereditary cardiac arrhythmias result from mutations in various genes encoding ion channels. One major channelopathy is long QT syndrome, which has excel-lent genetic and clinical heterogeneity. Arrhythmogenic right ventricular cardiomyopathy, another hereditary arrhythmia type, also shows high genetic heterogeneity and variable expressivity. Next-generation sequencing is an effective tool to reveal the dis-ease’s underlying genetic etiology.

Methods: In this study, we performed clinical exome sequencing or gene panel including cardiac arrhythmia and cardiomyopathy-associated genes by next-generation sequencing in 13 unrelated patients.

Results: Five pathogenic or likely pathogenic mutations, including three novel mutations, were found in the total cases.

Conclusion: This research shows a strong genetic heterogeneity in the disease. In addition, the study revealed that patients with QT interval prolongation on electrocardiogram might also have mutations in genes that are not associated with long QT syndrome, such as MYLK2 and DSG2. Therefore, our data helped expand the molecular scope of long QT syndrome. It is necessary to study with a broad perspective to elucidate the underly-ing molecular etiology in patients with hereditary cardiac arrhythmias.

Keywords: Arrhythmia, ARVC, clinical exome sequencing, genetics, LQTS

Hanife Saat, Ibrahim Şahin, Haktan Bagğış Erdem, Senem Özgür, Semiha Terlemez Tokgöz, Taha Bahsi&775;. Molecular Approach of Hereditary Arrhythmias, Long QT Syndrome, and Arrhythmogenic Right Ventricular Cardiomyopathy. Anatol J Cardiol. 2022; 26(6): 460-465

Corresponding Author: Hanife Saat
Manuscript Language: English


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