Rapid increasing trend in air travel brings necessity of urgent approach to health situations such as heart failure (HF). The prevalence of HF was projected to be more than 8 million patients ≥18 years of age in 2030; Main factors that contribute to physiological changes to cardiovascular system during a flight are changes in cabin pressure, humidity, stress, prolonged mobility. Identifying patients at risk of pre/post and during air travel along with adequate care by physicians and crew would help in better outcomes and comfortable travel for patients with HF.