ISSN 2149-2263 | E-ISSN 2149-2271
The Anatolian Journal of Cardiology
On the use of computational models for the quantitative assessment of surgery in congenital heart disease [Anatol J Cardiol]
Anatol J Cardiol. 2005; 5(3): 202-209

On the use of computational models for the quantitative assessment of surgery in congenital heart disease

Simone Pittaccio1, Francesco Migliavacca1, Gabriele Dubini1, Ergin Koçyıldırım2, Marc R de Leval1
1Cardiothoracic Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK
2Cardiothoracic Unit, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom

The surgical repair of congenital heart disease often involves significant modifications to the circulatory tree. Resections, reconstructions, graft insertions and the deployment of implants and biomedical devices have an impact on local and systemic haemodynamics, which may be difficult to foresee or to assess quantitatively by clinical investigation alone. Mathematical models can be employed to visualise, estimate or predict events and physical quantities that are difficult to observe or measure, and can be successfully applied to the study of the pre- and post-operative physiology of cardiovascular malformations. This paper analyses the potentialities of computation fluid dynamics in this respect, outlining the method, its requirements and its limitations. Examples are given of lumped parameter models, axi-symmetric models, three-dimensional models, fluid-structure interaction simulations and multiscale computing applied to total cavo-pulmonary connection, aortic coarctation and aortic arch reconstruction

Keywords: Mathematical models; congenital heart disease; coarctation of aorta; total cavo-pulmonary connection; computational fluid dynamics.

Simone Pittaccio, Francesco Migliavacca, Gabriele Dubini, Ergin Koçyıldırım, Marc R de Leval. On the use of computational models for the quantitative assessment of surgery in congenital heart disease. Anatol J Cardiol. 2005; 5(3): 202-209
Manuscript Language: English


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